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dc.contributor.authorMalinowski, S.S.
dc.contributor.authorBarber, K.E.
dc.contributor.authorKishk, O.A.
dc.date.accessioned2020-04-27T19:48:56Z
dc.date.available2020-04-27T19:48:56Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083172587&doi=10.1186%2fs40814-018-0387-0&partnerID=40&md5=3ece54d6232b3beed2c46cb7eb7dd954
dc.identifier.urihttp://hdl.handle.net/10713/12658
dc.description.abstractObjectives: Anecdotally, several strategies have been suggested in order to improve tolerability of fish oil supplements, but there is little evidence supporting any of these strategies. The aim of this study was to determine if there is a difference among four methods of oral administration of fish oil supplementation in terms of tolerability and adherence. Methods: A randomized, prospective, open-label, four-arm pilot study was conducted on 60 healthy adult subjects randomized to different fish oil supplement administration methods with (1) milk, (2) food, (3) an empty stomach, and (4) frozen capsules prior to ingestion. Each subject was instructed to take two capsules three times daily for 30 consecutive days. Adherence was assessed by pill counts. Adverse effects were assessed by survey and patient exit interview. Results: No apparent differences were demonstrated among the four administration groups in terms of adherence, reasons for non-adherence, or self-reported adverse effects. Conclusions: Method of administration did not affect rates of adherence or incidence of adverse effects in a small cohort of healthy adults taking fish oil supplement capsules for 30 days. Trial registration: ClinicalTrials.gov NCT01471366. Registered November 16, 2011. Copyright The Author(s).en_US
dc.description.urihttps://doi.org/10.1186/s40814-018-0387-0en_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofPilot and Feasibility Studies
dc.subjectAdherenceen_US
dc.subjectAdverse effectsen_US
dc.subjectDocosahexaenoic aciden_US
dc.subjectEicosapentaenoic aciden_US
dc.subjectFish oilen_US
dc.subjectN-3 polyunsaturated fatty acidsen_US
dc.subjectSafetyen_US
dc.subjectTolerabilityen_US
dc.titleEffect of fish oil supplement administration method on tolerability and adherence: A randomized pilot clinical trialen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s40814-018-0387-0


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