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    Myristyltrimethylammonium Bromide (MYTAB) as a cationic surface agent to inhibit Streptococcus mutans Grown over dental resins: An in vitro study

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    Author
    Silva, P.A.M.
    Garcia, I.M.
    Melo, M.A.
    Date
    2020
    Journal
    Journal of Functional Biomaterials
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/jfb11010009
    Abstract
    This in vitro study evaluated the effect of myristyltrimethylammonium bromide (MYTAB) on the physical, chemical, and biological properties of an experimental dental resin. The resin was formulated with dental dimetacrylate monomers and a photoinitiator/co-initiator system. MYTAB was added at 0.5 (G0.5%), 1 (G1%), and 2 (G2%) wt %, and one group remained without MYTAB and was used as the control (GCtrl). The resins were analyzed for the polymerization kinetics, degree of conversion, ultimate tensile strength (UTS), antibacterial activity against Streptococcus mutans, and cytotoxicity against human keratinocytes. Changes in the polymerization kinetics profiling were observed, and the degree of conversion ranged from 57.36% (±2.50%) for G2% to 61.88% (±1.91%) for G0.5%, without a statistically significant difference among groups (p > 0.05). The UTS values ranged from 32.85 (±6.08) MPa for G0.5% to 35.12 (±5.74) MPa for GCtrl (p > 0.05). MYTAB groups showed antibacterial activity against biofilm formation from 0.5 wt % (p < 0.05) and against planktonic bacteria from 1 wt % (p < 0.05). The higher the MYTAB concentration, the higher the cytotoxic effect, without differences between GCtrl e G0.5% (p > 0.05). In conclusion, the addition of 0.5 wt % of MYTAB did not alter the physical and chemical properties of the dental resin and provided antibacterial activity without cytotoxic effect. Copyright 2020 by the authors.
    Sponsors
    This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES)-Finance Code 001.
    Keyword
    Anti-bacterial agents
    Biocompatible materials
    Biofilms
    Dental caries
    Dental materials
    Dentistry
    Quaternary ammonium compounds
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083314967&doi=10.3390%2fjfb11010009&partnerID=40&md5=caa4c64aa17a8a778ba8faa38b5c26e8; http://hdl.handle.net/10713/12649
    ae974a485f413a2113503eed53cd6c53
    10.3390/jfb11010009
    Scopus Count
    Collections
    UMB Open Access Articles 2020

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