Myristyltrimethylammonium Bromide (MYTAB) as a cationic surface agent to inhibit Streptococcus mutans Grown over dental resins: An in vitro study
Date
2020Journal
Journal of Functional BiomaterialsPublisher
MDPI AGType
Article
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This in vitro study evaluated the effect of myristyltrimethylammonium bromide (MYTAB) on the physical, chemical, and biological properties of an experimental dental resin. The resin was formulated with dental dimetacrylate monomers and a photoinitiator/co-initiator system. MYTAB was added at 0.5 (G0.5%), 1 (G1%), and 2 (G2%) wt %, and one group remained without MYTAB and was used as the control (GCtrl). The resins were analyzed for the polymerization kinetics, degree of conversion, ultimate tensile strength (UTS), antibacterial activity against Streptococcus mutans, and cytotoxicity against human keratinocytes. Changes in the polymerization kinetics profiling were observed, and the degree of conversion ranged from 57.36% (±2.50%) for G2% to 61.88% (±1.91%) for G0.5%, without a statistically significant difference among groups (p > 0.05). The UTS values ranged from 32.85 (±6.08) MPa for G0.5% to 35.12 (±5.74) MPa for GCtrl (p > 0.05). MYTAB groups showed antibacterial activity against biofilm formation from 0.5 wt % (p < 0.05) and against planktonic bacteria from 1 wt % (p < 0.05). The higher the MYTAB concentration, the higher the cytotoxic effect, without differences between GCtrl e G0.5% (p > 0.05). In conclusion, the addition of 0.5 wt % of MYTAB did not alter the physical and chemical properties of the dental resin and provided antibacterial activity without cytotoxic effect. Copyright 2020 by the authors.Sponsors
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES)-Finance Code 001.Keyword
Anti-bacterial agentsBiocompatible materials
Biofilms
Dental caries
Dental materials
Dentistry
Quaternary ammonium compounds
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083314967&doi=10.3390%2fjfb11010009&partnerID=40&md5=caa4c64aa17a8a778ba8faa38b5c26e8; http://hdl.handle.net/10713/12649ae974a485f413a2113503eed53cd6c53
10.3390/jfb11010009