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dc.contributor.authorCissé, Y.M.
dc.contributor.authorRussart, K.
dc.contributor.authorNelson, R.J.
dc.date.accessioned2020-04-27T19:48:53Z
dc.date.available2020-04-27T19:48:53Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083460594&doi=10.1371%2fjournal.pone.0231140&partnerID=40&md5=b27adade0e220d2324bef1517e442574
dc.identifier.urihttp://hdl.handle.net/10713/12643
dc.description.abstractFunctional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses are associated with disrupted endogenous gene transcriptional and endocrine cycles. However, few studies have addressed the multigenerational consequences of systemic circadian rhythm disruption. We hypothesized that parental exposure to dim LAN (dLAN) would alter innate immune and sickness responses to an endotoxin challenge in adult offspring gestated and reared in dark nights. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 8 weeks, then paired, mated, and thereafter housed under dark nights. Maternal exposure to dLAN prior to conception impaired febrile responses and increased splenic il-1 production in response to LPS in male offspring. Paternal pre-conception dLAN dampened offspring tnf-? expression in the hypothalamus, reduced serum bactericidal capacity, and dark phase locomotor activity. These changes occurred despite offspring being conceived, gestated, and reared under standard dark night conditions. Overall, these data suggest that dLAN has intergenerational effects on innate immunity and sickness responses. Copyright: 2020 Cissé, et al.en_US
dc.description.sponsorshipThis study was supported by grant from National Science Foundation IOS 11-18792 and National Institute of Environmental Health Sciences ES026890-02.en_US
dc.description.urihttps://doi.org/10.1371/journal.pone.0231140en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.subjectlight at nighten_US
dc.subjectpre-conceptionen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshImmune Systemen_US
dc.subject.meshImmunity, Innateen_US
dc.titleExposure to dim light at night prior to conception attenuates offspring innate immune responsesen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0231140


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