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    Exposure to dim light at night prior to conception attenuates offspring innate immune responses

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    Author
    Cissé, Y.M.
    Russart, K.
    Nelson, R.J.
    Date
    2020
    Journal
    PLoS ONE
    Publisher
    Public Library of Science
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1371/journal.pone.0231140
    Abstract
    Functional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses are associated with disrupted endogenous gene transcriptional and endocrine cycles. However, few studies have addressed the multigenerational consequences of systemic circadian rhythm disruption. We hypothesized that parental exposure to dim LAN (dLAN) would alter innate immune and sickness responses to an endotoxin challenge in adult offspring gestated and reared in dark nights. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 8 weeks, then paired, mated, and thereafter housed under dark nights. Maternal exposure to dLAN prior to conception impaired febrile responses and increased splenic il-1 production in response to LPS in male offspring. Paternal pre-conception dLAN dampened offspring tnf-? expression in the hypothalamus, reduced serum bactericidal capacity, and dark phase locomotor activity. These changes occurred despite offspring being conceived, gestated, and reared under standard dark night conditions. Overall, these data suggest that dLAN has intergenerational effects on innate immunity and sickness responses. Copyright: 2020 Cissé, et al.
    Sponsors
    This study was supported by grant from National Science Foundation IOS 11-18792 and National Institute of Environmental Health Sciences ES026890-02.
    Keyword
    light at night
    pre-conception
    Circadian Rhythm
    Immune System
    Immunity, Innate
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083460594&doi=10.1371%2fjournal.pone.0231140&partnerID=40&md5=b27adade0e220d2324bef1517e442574; http://hdl.handle.net/10713/12643
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0231140
    Scopus Count
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    UMB Open Access Articles 2020

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