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    Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019

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    Author
    Barlow, A.
    Landolf, K.M.
    Yeung, S.Y.A.
    Heavner, J.J.
    Claassen, C.W.
    Heavner, M.S.
    Date
    2020
    Journal
    Pharmacotherapy
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/phar.2398
    Abstract
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has evolved into an emergent global pandemic. Coronavirus disease 2019 (COVID‐19) can manifest on a spectrum of illness from mild disease to severe respiratory failure requiring intensive care unit (ICU) admission. As the incidence continues to rise at a rapid pace, critical care teams are faced with challenging treatment decisions. There is currently no widely accepted standard of care in the pharmacological management of patients with COVID‐19. Urgent identification of potential treatment strategies is a priority. Therapies include novel agents available in clinical trials or through compassionate use, and other drugs, repurposed antiviral and immune modulating therapies. Many have demonstrated in vitro or in vivo potential against other viruses that are similar to SARS‐CoV‐2. Critically ill patients with COVID‐19 have additional considerations related to adjustments for organ impairment and renal replacement therapies, complex lists of concurrent medications, limitations with drug administration and compatibility, and unique toxicities that should be evaluated when utilizing these therapies. The purpose of this review is to summarize practical considerations for pharmacotherapy in patients with COVID‐19, with the intent of serving as a resource for health care providers at the forefront of clinical care during this pandemic.
    Keyword
    Antivirals
    Critical care
    Cytochrome P450
    Dialysis
    Infectious disease
    Liver
    Pharmacokinetics
    Pharmacology
    Renal
    Coronavirus Disease 2019 (COVID-19)
    SARS‐CoV‐2
    Show allShow less
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083259068&doi=10.1002%2fphar.2398&partnerID=40&md5=a1a94ac6731e400b78180d8bb4224187; http://hdl.handle.net/10713/12639
    ae974a485f413a2113503eed53cd6c53
    10.1002/phar.2398
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles 2020

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