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dc.contributor.authorAkpa, O.M.
dc.contributor.authorAdebamowo, S.N.
dc.contributor.authorCVD Working Group of the H3Africa Consortium
dc.date.accessioned2020-04-21T19:42:24Z
dc.date.available2020-04-21T19:42:24Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083073493&doi=10.1161%2fHYPERTENSIONAHA.119.14147&partnerID=40&md5=d3980dfd4a6c504594d43e6c6ea2e47b
dc.identifier.urihttp://hdl.handle.net/10713/12617
dc.description.abstractHypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns and association of obesity with hypertension among 30 044 continental Africans. We harmonized data on hypertension (defined as previous diagnosis/use of antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) and obesity from 30 044 individuals in the Cardiovascular H3Africa Innovation Resource across 13 African countries. We analyzed data from population-based controls and the Entire Harmonized Dataset. Age-adjusted and crude proportions of hypertension were compared regionally, across sex, and between hypertension definitions. Logit generalized estimating equation was used to determine the independent association of obesity with hypertension (P value <5%). Participants were 56% women; with mean age 48.5±12.0 years. Crude proportions of hypertension (at BP≥140/90 mmHg) were 47.9% (95% CI, 47.4–48.5) for Entire Harmonized Dataset and 42.0% (41.1–42.7) for population-based controls and were significantly higher for the 130/80 mm Hg threshold at 59.3% (58.7–59.9) in population-based controls. The age-adjusted proportion of hypertension at BP≥140/90 mmHg was the highest among men (33.8% [32.1–35.6]), in western Africa (34.7% [33.3–36.2]), and in obese individuals (43.6%; 40.3–47.2). Obesity was independently associated with hypertension in population-based controls (adjusted odds ratio, 2.5 [2.3–2.7]) and odds of hypertension in obesity increased with increasing age from 2.0 (1.7–2.3) in younger age to 8.8 (7.4–10.3) in older age. Hypertension is common across multiple countries in Africa with 11.9% to 51.7% having BP≥140/90 mmHg and 39.5% to 69.4% with BP≥130/80 mmHg. Obese Africans were more than twice as likely to be hypertensive and the odds increased with increasing age.en_US
dc.description.urihttps://doi.org/10.1161/HYPERTENSIONAHA.119.14147en_US
dc.language.isoen_USen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofHypertension (Dallas, Tex. : 1979)
dc.subjectAfricaen_US
dc.subjectblood pressureen_US
dc.subjecthypertensionen_US
dc.subjectobesityen_US
dc.subjectrisk factorsen_US
dc.titleRegional Patterns and Association Between Obesity and Hypertension in Africa: Evidence From the H3Africa CHAIR Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/HYPERTENSIONAHA.119.14147
dc.identifier.pmid32172619


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