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dc.contributor.authorAgarwal, A.
dc.contributor.authorChen, A.
dc.contributor.authorRavindran, N.
dc.contributor.authorTo, C.
dc.contributor.authorThuluvath, P.J.
dc.date.accessioned2020-04-21T19:42:24Z
dc.date.available2020-04-21T19:42:24Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083093762&doi=10.1016%2fj.jceh.2020.03.001&partnerID=40&md5=e8f101180cdc8c094bbff8282bb192a3
dc.identifier.urihttp://hdl.handle.net/10713/12616
dc.description.abstractThe worldwide pandemic of COVID-19, caused by the virus SARS-CoV,-2 has continued to progress, and increasing information is becoming available about the incidence of digestive symptoms as well as abnormal liver-associated enzymes in patients who are infected. These are postulated to be related to the virus's use of ACE-2 receptors located on certain intestinal cells, cholangiocytes, and hepatocytes. This brief review summarizes the available limited data on digestive manifestations of COVID-19. A significant proportion of COVID-19 patients can present initially with only digestive complaints. The most common digestive symptoms are anorexia, nausea, vomiting, and diarrhea. Liver-related transaminases are elevated in a substantial proportion of patients, although generally only mildly elevated. Currently there is no firm evidence to suggest that severity of digestive symptoms corresponds to severity of COVID-19 clinical course, however, more severe alterations in liver enzymes may correlate with worse clinical course. Given use of antiviral and antibacterial agents in sicker patients, drug-induced liver injury cannot be ruled out either in these cases. Although viral RNA can be detected in stool, it is unclear whether fecal-oral transmission can be achieved by the virus. As further data becomes available, our understanding of the digestive manifestations of COVID-19 will continue to evolve.en_US
dc.description.urihttps://doi.org/10.1016/j.jceh.2020.03.001en_US
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Clinical and Experimental Hepatology
dc.subjectCoronavirus Disease 2019 (COVID-19)en_US
dc.subjectSARS-CoV-2en_US
dc.subject.meshSigns and Symptoms, Digestiveen_US
dc.subject.meshLiveren_US
dc.titleGastrointestinal and Liver Manifestations of COVID-19en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jceh.2020.03.001


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