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dc.contributor.authorSharma, S.
dc.contributor.authorOhrbach, R.
dc.contributor.authorGreenspan, J.D.
dc.date.accessioned2020-04-14T14:28:52Z
dc.date.available2020-04-14T14:28:52Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082677652&doi=10.1177%2f0022034520913247&partnerID=40&md5=1f619b771ccfd76ffe552d4725b0d88c
dc.identifier.urihttp://hdl.handle.net/10713/12554
dc.description.abstractThis study evaluates contributions of jaw injury and experimental pain sensitivity to risk of developing painful temporomandibular disorder (TMD). Data were from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) nested case-control study of incident painful TMD. Injury and subsequent onset of painful TMD were monitored prospectively for ≤5 y in a community-based sample of 409 US adults who did not have TMD when enrolled. At baseline, thermal-pressure and pinprick pain sensitivity, as potential effect modifiers, were measured using quantitative sensory testing. During follow-up, jaw injury from any of 9 types of potentially traumatic events was determined using quarterly (3-monthly) health update questionnaires. Study examiners classified incident painful TMD, yielding 233 incident cases and 176 matched controls. Logistic regression models, estimated incidence odds ratios (IORs), and 95% confidence limits (CLs) were used for the association between injury and subsequent onset of painful TMD. During follow-up, 38.2% of incident cases and 13.1% of controls reported 1 or more injuries that were 4 times as likely to be intrinsic (i.e., sustained mouth opening or yawning) as extrinsic (e.g., dental visits, whiplash). Injuries due to extrinsic events (IOR = 7.6; 95% CL, 1.6 - 36.2), sustained opening (IOR = 5.4; 95% CL, 2.4 - 12.2), and yawning (IOR = 3.4; 95% CL, 1.6 - 7.3) were associated with increased TMD incidence. Both a single injury (IOR = 6.0; 95% CL, 2.9 - 12.4) and multiple injuries (IOR = 9.4; 95% CL, 3.4,25.6) predicted greater incidence of painful TMD than events perceived as noninjurious (IOR = 1.9; 95% CL, 1.1 - 3.4). Injury-associated risk of painful TMD was elevated in people with high sensitivity to heat pain (IOR = 7.4; 95% CL, 3.1 - 18.0) compared to people with low sensitivity to heat pain (IOR = 3.9; 95% CL, 1.7 - 8.4). Jaw injury was strongly associated with elevated painful TMD risk, and the risk was amplified in subjects who had enhanced sensitivity to heat pain at enrollment. Commonly occurring but seemingly innocuous events, such as yawning injury, should not be overlooked when judging prognostic importance of jaw injury. Copyright The Author(s) 2020.en_US
dc.description.sponsorshipThis work was supported by the National Institutes of Health and National Institutes of Dental and Craniofacial Research grant U01-DE017018 (OPPERA) and training grant T32-DE023526 (awarded to the Department of Oral Biology, University at Buffalo).en_US
dc.description.urihttps://doi.org/10.1177/0022034520913247en_US
dc.language.isoen_USen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofJournal of Dental Research
dc.subjectcentral sensitizationen_US
dc.subjectincidenceen_US
dc.subjectpain thresholden_US
dc.subjectprospective studiesen_US
dc.subjectrisk factorsen_US
dc.subjecttemporomandibular joint disordersen_US
dc.titlePain Sensitivity Modifies Risk of Injury-Related Temporomandibular Disorderen_US
dc.typeArticleen_US
dc.identifier.doi10.1177/0022034520913247


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