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    Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells

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    Author
    Turri, V.
    Latinovic, O.S.
    Toyang, N.
    Date
    2020
    Journal
    BioMed Research International
    Publisher
    Hindawi Limited
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1155/2020/7465242
    Abstract
    Recent comparisons between plant and animal viruses reveal many common principles that underlie how all viruses express their genetic material, amplify their genomes, and link virion assembly with replication. Cauliflower mosaic virus (CaMV) is not infectious for human beings. Here, we show that CaMV transactivator/viroplasmin protein (TAV) shares sequence similarity with and behaves like the human ribonuclease H1 (RNase H1) in reducing DNA/RNA hybrids detected with S9.6 antibody in HEK293T cells. We showed that TAV is clearly expressed in the cytosol and in the nuclei of transiently transfected human cells, similar to its distribution in plants. TAV also showed remarkable cytotoxic effects in U251 human glioma cells in vitro. These characteristics pave the way for future analysis on the use of the plant virus protein TAV, as an alternative to human RNAse H1 during gene therapy in human cells. Copyright 2020 Valentina Turri et al.
    Sponsors
    Paul G. Allen Family Foundation: 12147
    Keyword
    transactivator/viroplasmin protein
    ribonuclease H1
    human glioma cells
    Caulimovirus
    Plant Viruses
    Humans
    Cytotoxins
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082880361&doi=10.1155%2f2020%2f7465242&partnerID=40&md5=a3f8fc3614713245ba51cf1105b50512; http://hdl.handle.net/10713/12550
    ae974a485f413a2113503eed53cd6c53
    10.1155/2020/7465242
    Scopus Count
    Collections
    UMB Open Access Articles 2020

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