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dc.contributor.authorMedeiros, P.H.Q.S.
dc.contributor.authorBolick, D.T.
dc.contributor.authorBarry, E.M.
dc.date.accessioned2020-04-14T14:28:46Z
dc.date.available2020-04-14T14:28:46Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082751265&doi=10.1038%2fs41541-020-0180-y&partnerID=40&md5=7a53678d7e4654fc0dd7f859c9ad2e00
dc.identifier.urihttp://hdl.handle.net/10713/12537
dc.description.abstractVaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans. Copyright 2020, The Author(s).en_US
dc.description.sponsorshipThis work was supported by National Institutes of Health (NIH) under NIH Award Number U19 AI109776 (CETR, Centers for Excellence for Translational Research, PI Myron Levine) from the National Institute of Allergy and Infectious Diseases (NIAID); and by Bill & Melinda Gates Foundation under Opportunity ID OPP1137923 (Host, pathogen and pathogen interaction determinants of environmental enteric dysfunction). National Institutes of Health, NIH: U19 AI109776 Israeli Centers for Research Excellence, I-COREen_US
dc.description.urihttps://doi.org/10.1038/s41541-020-0180-yen_US
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.ispartofnpj Vaccines
dc.subjectpreclinical researchen_US
dc.subject.meshBacterial Infectionsen_US
dc.subject.meshShigella flexnerien_US
dc.subject.meshEnterotoxigenic Escherichia colien_US
dc.subject.meshVaccinesen_US
dc.subject.meshMiceen_US
dc.titleA bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41541-020-0180-y


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