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dc.contributor.authorMorgan, C.P.
dc.contributor.authorShetty, A.
dc.contributor.authorCisse, Y.M.
dc.contributor.authorNugent, B.M.
dc.contributor.authorMorrison, K.E.
dc.contributor.authorHuang, W.
dc.contributor.authorKanyuch, N.
dc.contributor.authorAment, S.
dc.contributor.authorKane, M.
dc.contributor.authorBale, T.L.
dc.contributor.authorJašarević, E.
dc.date.accessioned2020-04-03T15:58:16Z
dc.date.available2020-04-03T15:58:16Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082148006&doi=10.1038%2fs41467-020-15305-w&partnerID=40&md5=ca411d0e27032aed8a91fbd22be8e6c8
dc.identifier.urihttp://hdl.handle.net/10713/12480
dc.description.abstractExtracellular vesicles (EVs) are a unique mode of intercellular communication capable of incredible specificity in transmitting signals involved in cellular function, including germ cell maturation. Spermatogenesis occurs in the testes, behind a protective barrier to ensure safeguarding of germline DNA from environmental insults. Following DNA compaction, further sperm maturation occurs in the epididymis. Here, we report reproductive tract EVs transmit information regarding stress in the paternal environment to sperm, potentially altering fetal development. Using intracytoplasmic sperm injection, we found that sperm incubated with EVs collected from stress-treated epididymal epithelial cells produced offspring with altered neurodevelopment and adult stress reactivity. Proteomic and transcriptomic assessment of these EVs showed dramatic changes in protein and miRNA content long after stress treatment had ended, supporting a lasting programmatic change in response to chronic stress. Thus, EVs as a normal process in sperm maturation, can also perform roles in intergenerational transmission of paternal environmental experience.en_US
dc.description.urihttps://doi.org/10.1038/s41467-020-15305-wen_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature communications
dc.titleReproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopmenten_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-020-15305-w
dc.identifier.pmid32198406


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