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    Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

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    Author
    Morgan, C.P.
    Shetty, A.
    Cisse, Y.M.
    Nugent, B.M.
    Morrison, K.E.
    Huang, W.
    Kanyuch, N.
    Ament, S.
    Kane, M.
    Bale, T.L.
    Jašarević, E.
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    Date
    2020
    Journal
    Nature communications
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
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    See at
    https://doi.org/10.1038/s41467-020-15305-w
    Abstract
    Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of incredible specificity in transmitting signals involved in cellular function, including germ cell maturation. Spermatogenesis occurs in the testes, behind a protective barrier to ensure safeguarding of germline DNA from environmental insults. Following DNA compaction, further sperm maturation occurs in the epididymis. Here, we report reproductive tract EVs transmit information regarding stress in the paternal environment to sperm, potentially altering fetal development. Using intracytoplasmic sperm injection, we found that sperm incubated with EVs collected from stress-treated epididymal epithelial cells produced offspring with altered neurodevelopment and adult stress reactivity. Proteomic and transcriptomic assessment of these EVs showed dramatic changes in protein and miRNA content long after stress treatment had ended, supporting a lasting programmatic change in response to chronic stress. Thus, EVs as a normal process in sperm maturation, can also perform roles in intergenerational transmission of paternal environmental experience.
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082148006&doi=10.1038%2fs41467-020-15305-w&partnerID=40&md5=ca411d0e27032aed8a91fbd22be8e6c8; http://hdl.handle.net/10713/12480
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-020-15305-w
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