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dc.contributor.authorFishman, P.S.
dc.contributor.authorGass, J.S.
dc.contributor.authorSwoveland, P.T.
dc.date.accessioned2020-03-27T15:13:19Z
dc.date.available2020-03-27T15:13:19Z
dc.date.issued1985
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d
dc.identifier.urihttp://hdl.handle.net/10713/12438
dc.description.abstractThe coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.en_US
dc.description.urihttps://doi.org/10.1126/science.2992088en_US
dc.language.isoen_USen_US
dc.relation.ispartofScience
dc.subjectmouse hepatitis virus strain A59en_US
dc.subject.meshCoronavirus Infectionsen_US
dc.subject.meshEncephalitisen_US
dc.subject.meshParkinson Disease, Postencephaliticen_US
dc.titleInfection of the basal ganglia by a murine coronavirusen_US
dc.typeArticleen_US
dc.identifier.doi10.1126/science.2992088
dc.identifier.pmid2992088
dc.identifier.ispublishedYes
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