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AbstractThe coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.
Keywordmouse hepatitis virus strain A59
Parkinson Disease, Postencephalitic
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d; http://hdl.handle.net/10713/12438