Abstract
The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.Keyword
mouse hepatitis virus strain A59Coronavirus Infections
Encephalitis
Parkinson Disease, Postencephalitic
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d; http://hdl.handle.net/10713/12438ae974a485f413a2113503eed53cd6c53
10.1126/science.2992088
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