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    Infection of the basal ganglia by a murine coronavirus

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    Author
    Fishman, P.S.
    Gass, J.S.
    Swoveland, P.T.
    Date
    1985
    Journal
    Science
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1126/science.2992088
    Abstract
    The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.
    Keyword
    mouse hepatitis virus strain A59
    Coronavirus Infections
    Encephalitis
    Parkinson Disease, Postencephalitic
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d; http://hdl.handle.net/10713/12438
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.2992088
    Scopus Count
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    UMB Coronavirus Publications

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