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dc.contributor.authorColeman, C.M.
dc.contributor.authorVenkataraman, T.
dc.contributor.authorFrieman, M.B.
dc.date.accessioned2020-03-27T15:13:17Z
dc.date.available2020-03-27T15:13:17Z
dc.date.issued2014
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84902176510&doi=10.1128%2fAAC.03036-14&partnerID=40&md5=c82f3f5e8c97b8be79573df306c340a6
dc.identifier.urihttp://hdl.handle.net/10713/12417
dc.description.abstractOutbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options. Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health agencies, drug developers, and funding agencies. Given the development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses. In the studies described here, a library of 290 compounds was screened for antiviral activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). Selection of compounds for inclusion in the library was dependent on current or previous FDA approval or advanced clinical development. Some drugs that had a well-defined cellular pathway as target were included. In total, 27 compounds with activity against both MERS-CoV and SARS-CoV were identified. The compounds belong to 13 different classes of pharmaceuticals, including inhibitors of estrogen receptors used for cancer treatment and inhibitors of dopamine receptor used as antipsychotics. The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies.en_US
dc.description.urihttps://doi.org/10.1128/AAC.03036-14en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.subjectMERS-CoVen_US
dc.subjectSARS-CoVen_US
dc.subjectdrug repurposingen_US
dc.subject.meshMiddle East Respiratory Syndrome Coronavirusen_US
dc.subject.meshSARS Virusen_US
dc.subject.meshCoronavirus Infections--therapyen_US
dc.subject.meshAntiviral Agentsen_US
dc.subject.meshDrug Repositioningen_US
dc.titleRepurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/AAC.03036-14
dc.identifier.pmid24841273
dc.identifier.ispublishedNo


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