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dc.contributor.authorAdedeji, A.O.
dc.contributor.authorSingh, K.
dc.contributor.authorColeman, C.M.
dc.date.accessioned2020-03-27T15:13:17Z
dc.date.available2020-03-27T15:13:17Z
dc.date.issued2014
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84903978961&doi=10.1128%2fAAC.02994-14&partnerID=40&md5=56a71c3c2340a0d8305b36eab098b4e3
dc.identifier.urihttp://hdl.handle.net/10713/12416
dc.description.abstractWe have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.en_US
dc.description.sponsorshipNational Institutes of Health, NIH: P50GM103368, R01AI076119, R01AI095569, R01AI099284, R01AI100890, R21AI079801, R21AI112417, R33AI079801en_US
dc.description.urihttps://doi.org/10.1128/AAC.02994-14en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.subjectreplication inhibitoren_US
dc.subjectSSYA10-001en_US
dc.subjectSARS-CoVen_US
dc.subjectMERS-CoVen_US
dc.subjectMHVen_US
dc.subjectmouse hepatitis virusen_US
dc.subject.meshMiddle East Respiratory Syndrome Coronavirusen_US
dc.subject.meshSARS Virusen_US
dc.subject.meshMurine hepatitis virusen_US
dc.subject.meshCoronavirus Infectionsen_US
dc.titleEvaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronavirusesen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/AAC.02994-14
dc.identifier.pmid24841268
dc.identifier.ispublishedNo


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