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    Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

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    Author
    Adedeji, A.O.
    Singh, K.
    Coleman, C.M.
    Date
    2014
    Journal
    Antimicrobial Agents and Chemotherapy
    Publisher
    American Society for Microbiology
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1128/AAC.02994-14
    Abstract
    We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.
    Sponsors
    National Institutes of Health, NIH: P50GM103368, R01AI076119, R01AI095569, R01AI099284, R01AI100890, R21AI079801, R21AI112417, R33AI079801
    Keyword
    replication inhibitor
    SSYA10-001
    SARS-CoV
    MERS-CoV
    MHV
    mouse hepatitis virus
    Middle East Respiratory Syndrome Coronavirus
    SARS Virus
    Murine hepatitis virus
    Coronavirus Infections
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903978961&doi=10.1128%2fAAC.02994-14&partnerID=40&md5=56a71c3c2340a0d8305b36eab098b4e3; http://hdl.handle.net/10713/12416
    ae974a485f413a2113503eed53cd6c53
    10.1128/AAC.02994-14
    Scopus Count
    Collections
    UMB Coronavirus Publications

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