Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses
Date
2014Journal
Antimicrobial Agents and ChemotherapyPublisher
American Society for MicrobiologyType
Article
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Show full item recordAbstract
We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.Sponsors
National Institutes of Health, NIH: P50GM103368, R01AI076119, R01AI095569, R01AI099284, R01AI100890, R21AI079801, R21AI112417, R33AI079801Keyword
replication inhibitorSSYA10-001
SARS-CoV
MERS-CoV
MHV
mouse hepatitis virus
Middle East Respiratory Syndrome Coronavirus
SARS Virus
Murine hepatitis virus
Coronavirus Infections
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903978961&doi=10.1128%2fAAC.02994-14&partnerID=40&md5=56a71c3c2340a0d8305b36eab098b4e3; http://hdl.handle.net/10713/12416ae974a485f413a2113503eed53cd6c53
10.1128/AAC.02994-14
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