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dc.contributor.authorMatthews, K.L.
dc.contributor.authorColeman, C.M.
dc.contributor.authorFrieman, M.B.
dc.date.accessioned2020-03-27T15:13:16Z
dc.date.available2020-03-27T15:13:16Z
dc.date.issued2014
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84897055458&doi=10.1099%2fvir.0.062059-0&partnerID=40&md5=65870b91651def8b827047d61fcd78f1
dc.identifier.urihttp://hdl.handle.net/10713/12415
dc.description.abstractThe recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely related to those of two bat coronaviruses, named BtCoV-HKU4 and BtCoV-HKU5, which were derived from Chinese bat samples. A hallmark of highly pathogenic respiratory viruses is their ability to evade the innate immune response of the host. CoV accessory proteins, for example those from severe acute respiratory syndrome CoV (SARS-CoV), have been shown to block innate antiviral signalling pathways. MERS-CoV, similar to SARS-CoV, has been shown to inhibit type I IFN induction in a variety of cell types in vitro. We therefore hypothesized that MERS-CoV and the phylogenetically related BtCoV-HKU4 and BtCoV-HKU5 may encode proteins with similar capabilities. In this study, we have demonstrated that the ORF4b-encoded accessory protein (p4b) of MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 may indeed facilitate innate immune evasion by inhibiting the type I IFN and NF-κB signalling pathways. We also analysed the subcellular localization of p4b from MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 and demonstrated that all are localized to the nucleus.en_US
dc.description.urihttps://doi.org/10.1099/vir.0.062059-0en_US
dc.language.isoen_USen_US
dc.publisherSociety for General Microbiologyen_US
dc.relation.ispartofJournal of General Virology
dc.subjectMERS-CoVen_US
dc.subjectSARS-CoVen_US
dc.subjectORF4b-encoded accessory proteinen_US
dc.subjectp4ben_US
dc.subjectbat coronavirusesen_US
dc.subjectprotein inhibitorsen_US
dc.subject.meshMiddle East Respiratory Syndrome Coronavirusen_US
dc.subject.meshSARS Virusen_US
dc.subject.meshCoronavirus Infectionsen_US
dc.subject.meshBetacoronavirusen_US
dc.titleThe ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signallingen_US
dc.typeArticleen_US
dc.identifier.doi10.1099/vir.0.062059-0
dc.identifier.pmid24443473
dc.identifier.ispublishedNo


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