Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus
JournalJournal of General Virology
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AbstractThe Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a small animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We found that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be due to the low level of mRNA and protein for the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV.
SponsorsNational Institutes of Health, NIH: RO1 AI 095569-01
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84892579594&doi=10.1099%2fvir.0.060640-0&partnerID=40&md5=d52d535dda8958bfd82c5b4546490dab; http://hdl.handle.net/10713/12413