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    Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

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    Author
    Coleman, C.M.
    Berrebi, A.
    Sisk, J.M.
    Matthews, K.L.
    Frieman, M.B.
    Date
    2015
    Journal
    Proceedings of the National Academy of Sciences of the United States of America
    Publisher
    National Academy of Sciences
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1073/pnas.1510830112
    Abstract
    Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections hinders the in vivo testing of potential therapeutics. Here we demonstrate the use of the VelocImmune technology (a mouse that expresses human antibody-variable heavy chains and ? light chains) alongside the VelociGene technology (which allows for rapid engineering of the mouse genome) to quickly develop and evaluate antibodies against an emerging viral disease. Specifically, we show the rapid generation of fully human neutralizing antibodies against the recently emerged Middle East Respiratory Syndrome coronavirus (MERS-CoV) and development of a humanized mouse model for MERS-CoV infection, which was used to demonstrate the therapeutic efficacy of the isolated antibodies. The VelocImmune and VelociGene technologies are powerful platforms that can be used to rapidly respond to emerging epidemics.
    Keyword
    DPP4
    MERS-CoV
    Mouse model
    Neutralizing antibody
    Spike
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937107017&doi=10.1073%2fpnas.1510830112&partnerID=40&md5=ba32413c1ad77dce2a80e340f0bbf9e1; http://hdl.handle.net/10713/12405
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1510830112
    Scopus Count
    Collections
    UMB Coronavirus Publications

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