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    Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens

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    Author
    Sisk, J.M.
    Frieman, M.B.
    Date
    2016
    Journal
    ACS Infectious Diseases
    Publisher
    American Chemical Society
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1021/acsinfecdis.5b00089
    Abstract
    The current outbreaks of Middle East Respiratory Syndrome (MERS) and Ebolavirus (EboV) have revealed a gap in the development and availability of drugs to treat these infections. To date, there are no approved treatments for patients infected with MERS coronavirus (MERS-CoV), a virus that continues to infect new patients and that has now spread from the Middle East to Asia. Despite a downward trend in the number of new EboV cases in West Africa, new infections are still occurring, and many patients continue to suffer from this illness. People infected with MERS and Ebola viruses receive only supportive care in hopes of recovery. Investigation into repurposing drugs approved by the FDA is gaining interest. To identify better treatment strategies, several groups have used drug screens to repurpose FDA-approved drugs as inhibitors of MERS-CoV and EboV.
    Keyword
    Food and Drug Administration-approved drugs
    drug screening
    Drug Evaluation, Preclinical
    Middle East Respiratory Syndrome Coronavirus
    Ebolavirus
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969219474&doi=10.1021%2facsinfecdis.5b00089&partnerID=40&md5=b0f3732fc413098185e317dec8c4583f; http://hdl.handle.net/10713/12404
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsinfecdis.5b00089
    Scopus Count
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    UMB Coronavirus Publications

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