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dc.contributor.authorVenkataraman, T.
dc.contributor.authorFrieman, M.B.
dc.date.accessioned2020-03-27T15:13:14Z
dc.date.available2020-03-27T15:13:14Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018490378&doi=10.1016%2fj.antiviral.2017.03.022&partnerID=40&md5=cb73aed3e046ecc12e7743ef2bc0d331
dc.identifier.urihttp://hdl.handle.net/10713/12399
dc.description.abstractMany survivors of the 2003 outbreak of severe acute respiratory syndrome (SARS) developed residual pulmonary fibrosis with increased severity seen in older patients. Autopsies of patients that died from SARS also showed fibrosis to varying extents. Pulmonary fibrosis can be occasionally seen as a consequence to several respiratory viral infections but is much more common after a SARS coronavirus (SARS-CoV) infection. Given the threat of future outbreaks of severe coronavirus disease, including Middle East respiratory syndrome (MERS), it is important to understand the mechanisms responsible for pulmonary fibrosis, so as to support the development of therapeutic countermeasures and mitigate sequelae of infection. In this article, we summarize pulmonary fibrotic changes observed after a SARS-CoV infection, discuss the extent to which other respiratory viruses induce fibrosis, describe available animal models to study the development of SARS-CoV induced fibrosis and review evidence that pulmonary fibrosis is caused by a hyperactive host response to lung injury mediated by epidermal growth factor receptor (EGFR) signaling. We summarize work from our group and others indicating that inhibiting EGFR signaling may prevent an excessive fibrotic response to SARS-CoV and other respiratory viral infections and propose directions for future research.en_US
dc.description.urihttps://doi.org/10.1016/j.antiviral.2017.03.022en_US
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofAntiviral Research
dc.subjectEGFRen_US
dc.subjectFibrosisen_US
dc.subjectSARS-CoVen_US
dc.subjectWound healingen_US
dc.titleThe role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.antiviral.2017.03.022
dc.identifier.pmid28390872
dc.identifier.ispublishedNo


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