Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies
Date
2017Journal
DrugsPublisher
Springer International PublishingType
Article
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No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed. The main focus of the review is on drug development and the potential that drugs approved for other indications provide for repurposing. The drugs we discuss belong to a wide range of different drug classes, such as cancer therapeutics, antipsychotics, and antimalarials. In addition to their activity against MERS and SARS coronaviruses, many of these approved drugs have broad-spectrum potential and have already been in clinical use for treating other viral infections. A wealth of knowledge is available for these drugs. However, the information in this review is not meant to guide clinical decisions, and any therapeutic described here should only be used in context of a clinical trial. Potential targets for novel antivirals and antibodies are discussed as well as lessons learned from treatment development for other RNA viruses. The article concludes with a discussion of the gaps in our knowledge and areas for future research on emerging coronaviruses.Sponsors
Funding This work was supported in part by the Division of Intramural Research and Division of Clinical Research, National Institute of Allergy and Infectious Diseases. This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I.Keyword
Middle East Respiratory Syndrome CoronavirusSevere Acute Respiratory Syndrome
Drug Therapy
SARS Virus
Coronavirus Infections
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034083736&doi=10.1007%2fs40265-017-0830-1&partnerID=40&md5=32b04da678f019a22f9c7f5dc98e5722; http://hdl.handle.net/10713/12398ae974a485f413a2113503eed53cd6c53
10.1007/s40265-017-0830-1
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