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    Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies

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    Author
    Dyall, J.
    Gross, R.
    Frieman, M.B.
    Date
    2017
    Journal
    Drugs
    Publisher
    Springer International Publishing
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s40265-017-0830-1
    Abstract
    No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed. The main focus of the review is on drug development and the potential that drugs approved for other indications provide for repurposing. The drugs we discuss belong to a wide range of different drug classes, such as cancer therapeutics, antipsychotics, and antimalarials. In addition to their activity against MERS and SARS coronaviruses, many of these approved drugs have broad-spectrum potential and have already been in clinical use for treating other viral infections. A wealth of knowledge is available for these drugs. However, the information in this review is not meant to guide clinical decisions, and any therapeutic described here should only be used in context of a clinical trial. Potential targets for novel antivirals and antibodies are discussed as well as lessons learned from treatment development for other RNA viruses. The article concludes with a discussion of the gaps in our knowledge and areas for future research on emerging coronaviruses.
    Sponsors
    Funding This work was supported in part by the Division of Intramural Research and Division of Clinical Research, National Institute of Allergy and Infectious Diseases. This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I.
    Keyword
    Middle East Respiratory Syndrome Coronavirus
    Severe Acute Respiratory Syndrome
    Drug Therapy
    SARS Virus
    Coronavirus Infections
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034083736&doi=10.1007%2fs40265-017-0830-1&partnerID=40&md5=32b04da678f019a22f9c7f5dc98e5722; http://hdl.handle.net/10713/12398
    ae974a485f413a2113503eed53cd6c53
    10.1007/s40265-017-0830-1
    Scopus Count
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    UMB Coronavirus Publications

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