• COVID-19 and Lessons to be Learned from Prior Coronavirus Outbreaks

      Deming, M.E.; Chen, W.H. (American Thoracic Society, 2020)
      Coronaviruses are large RNA viruses that are endemic among bats globally. These bat viruses are known to readily recombine and present an ever-present potential to jump host species, allowing for emergence into novel hosts.[1] Four seasonal human coronaviruses (hCoV) circulate yearly as mild “common cold” viruses causing upper respiratory symptoms: OC43, HKU1, NL63, and 229E. Additionally, three novel coronaviruses have emerged as zoonotic human infections in the past 17 years. SARS-coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV), and the 2019 novel coronavirus (SARS-CoV-2)[2] have each been associated with lower respiratory symptoms, progressing in a subset of individuals to acute respiratory distress syndrome (ARDS) and death.