• Booster of mRNA-1273 Vaccine Reduces SARS-CoV-2 Omicron Escape from Neutralizing Antibodies.

      Doria-Rose, Nicole A; Shen, Xiaoying; Schmidt, Stephen D; O'Dell, Sijy; McDanal, Charlene; Feng, Wenhong; Tong, Jin; Eaton, Amanda; Maglinao, Maha; Tang, Haili; et al. (Cold Spring Harbor Laboratory, 2021-12-15)
      The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G and 5.3-7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 µg mRNA-1273. A 50 µg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.
    • SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination.

      Pajon, Rolando; Doria-Rose, Nicole A; Shen, Xiaoying; Schmidt, Stephen D; O'Dell, Sijy; McDanal, Charlene; Feng, Wenhong; Tong, Jin; Eaton, Amanda; Maglinao, Maha; et al. (Massachusetts Medical Society, 2022-01-26)