Browsing UMB Coronavirus Publications by Author "Schultz, Marcus J"
Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare WorkersStilma, Willemke; Åkerman, Eva; Artigas, Antonio; Bentley, Andrew; Bos, Lieuwe D; Bosman, Thomas J C; de Bruin, Hendrik; Brummaier, Tobias; Buiteman-Kruizinga, Laura A; Carcò, Francesco; et al. (American Society of Tropical Medicine and Hygiene, 2021-03-11)Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and uncertainties regarding potential benefits and practical application. To summarize evidence for benefit and to develop a set of pragmatic recommendations for awake proning in patients with COVID-19 pneumonia, focusing on settings where resources are limited, international healthcare professionals from high and low- and middle-income countries (LMICs) with known expertise in awake proning were invited to contribute expert advice. Agrowing number of observational studies describe the effects of awake proning in patients with COVID-19 pneumonia in whom hypoxemia is refractory to simple measures of supplementary oxygen. Awake proning improves oxygenation in most patients, usually within minutes, and reduces dyspnea and work of breathing. The effects are maintained for up to 1 hour after turning back to supine, and mostly disappear after 6-12 hours. In available studies, awake proning was not associated with a reduction in the rate of intubation for invasive ventilation. Awake proning comes with little complications if properly implemented and monitored. Pragmatic recommendations including indications and contraindications were formulated and adjusted for resource-limited settings. Awake proning, an adjunctive treatment for hypoxemia refractory to supplemental oxygen, seems safe in non-intubated patients with COVID-19 acute respiratory failure. We provide pragmatic recommendations including indications and contraindications for the use of awake proning in LMICs. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene.
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi methodNasa, Prashant; Azoulay, Elie; Khanna, Ashish K; Jain, Ravi; Gupta, Sachin; Javeri, Yash; Juneja, Deven; Rangappa, Pradeep; Sundararajan, Krishnaswamy; Alhazzani, Waleed; et al. (Springer Nature, 2021-03-16)Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the respiratory management of C-ARF in areas where evidence is absent or limited. Agreement was defined as achieved when > 70% experts voted for a given option on the Likert scale statement or > 80% voted for a particular option in multiple-choice questions. Stability was assessed between the two concluding rounds for each statement, using the non-parametric Chi-square (χ2) test (p < 0·05 was considered as unstable).