• Impaired Immune Response to COVID-19 Vaccination in Patients with B-Cell Malignancies after CD19 CART Cell Therapy

      Dahiya, Saurabh; Luetkens, Tim; Lutfi, Forat; Avila, Stephanie V.; Iraguha, Thierry; Margiotta, Philip J; Hankey, Kim G.; Lesho, Patricia; Law, Jennie Y.; Lee, Seung Tae; et al. (American Society of Hematology, 2021-12-23)
    • Overview of COVID-19-Associated Invasive Fungal Infection

      Shishido, Akira A.; Mathew, Minu; Baddley, John W. (Springer Nature, 2022-07-11)
      PURPOSE OF REVIEW: Invasive fungal infections are a complication of COVID-19 disease. This article reviews literature characterizing invasive fungal infections associated with COVID-19. RECENT FINDINGS: Multiple invasive fungal infections including aspergillosis, candidiasis, pneumocystosis, other non-Aspergillus molds, and endemic fungi have been reported in patients with COVID-19. Risk factors for COVID-19-associated fungal disease include underlying lung disease, diabetes, steroid or immunomodulator use, leukopenia, and malignancy. COVID-19-associated pulmonary aspergillosis (CAPA) and COVID-19-associated mucormycosis (CAM) are the most common fungal infections described. However, there is variability in the reported incidences related to use of differing diagnostic algorithms. SUMMARY: Fungal pathogens are important cause of infection in patients with COVID-19, and the diagnostic strategies continue to evolve. Mortality in these patients is increased, and providers should operate with a high index of suspicion. Further studies will be required to elucidate the associations and pathogenesis of these diseases and best management and prevention strategies.