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    Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans

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    Author
    Doumatey, A.P.
    Adebamowo, S.N.
    Adebamowo, C.
    Date
    2020
    Journal
    Frontiers in Cellular and Infection Microbiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fcimb.2020.00063
    Abstract
    Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome composition in relation to type 2 diabetes (T2D) in Africans. Here, we describe the profile of the gut microbiome in non-diabetic adults (controls) and investigate the association between gut microbiota and T2D in urban West Africans. Gut microbiota composition was determined in 291 Nigerians (98 cases, 193 controls) using fecal 16S V4 rRNA gene sequencing done on the Illumina MiSeq platform. Data analysis of operational taxonomic units (OTU) was conducted to describe microbiome composition and identify differences between T2D and controls. The most abundant phyla were Firmicutes, Actinobacteria, and Bacteroidetes. Clostridiaceae, and Peptostreptococcaceaea were significantly lower in cases than controls (p < 0.001). Feature selection analysis identified a panel of 18 OTUs enriched in cases that included Desulfovibrio piger, Prevotella, Peptostreptococcus, and Eubacterium. A panel of 17 OTUs that was enriched in the controls included Collinsella, Ruminococcus lactaris, Anaerostipes, and Clostridium. OTUs with strain-level annotation showing the largest fold-change included Cellulosilyticum ruminicola (log2FC = −3.1; p = 4.2 × 10−5), Clostridium paraputrificum (log2FC = −2.5; p = 0.005), and Clostridium butyricum (log2FC = −1.76; p = 0.01), all lower in cases. These findings are notable because supplementation with Clostridium butyricum and Desulfovibrio piger has been shown to improve hyperglycemia and reduce insulin resistance in murine models. This first investigation of gut microbiome and diabetes in urban Africans shows that T2D is associated with compositional changes in gut microbiota highlighting the possibility of developing strategies to improve glucose control by modifying bacterial composition in the gut. Copyright 2020 The Authors.
    Sponsors
    unding. The Africa America Diabetes Mellitus (AADM) study was supported by NIH Grant No. 3T37TW00041-03S2 from the National Institute on Minority Health and Health Disparities.
    Keyword
    16S V4 rRNA sequencing
    gut microbiome
    microbial composition
    type 2 diabetes
    urban Africans
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081672337&doi=10.3389%2ffcimb.2020.00063&partnerID=40&md5=d9e80f2c34759218ad19e195eb7bcf1e; http://hdl.handle.net/10713/12378
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcimb.2020.00063
    Scopus Count
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    UMB Open Access Articles 2020

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