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dc.contributor.authorSerra, M.C.
dc.contributor.authorRyan, A.S.
dc.contributor.authorHafer-Macko, C.E.
dc.date.accessioned2020-03-23T15:54:13Z
dc.date.available2020-03-23T15:54:13Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081204858&doi=10.3390%2fnu12030701&partnerID=40&md5=3686a91b2c0301138a7a819b09f9c737
dc.identifier.urihttp://hdl.handle.net/10713/12314
dc.description.abstractThe purpose of this study was to quantify habitual dietary and systemic omega-6 and omega-3 fatty acids and their ratios and to determine their relationship with physical and metabolic function in a cohort of chronic adult stroke survivors. Twenty-five older chronic stroke survivors (age: 63 ± 8 years; BMI: 31 ± 7 kg/m2; mean ± SD) were assessed for fitness (VO2 peak), gait speed (GS), 3 m timed up and go (TUG), and six-minute walk distance (6MWD). Plasma lipid and glucose profiles were measured, and HOMA-IR calculated. Dietary (5-day food records) and serum (mass spectrometry) omega-6/omega-3 profiles were assessed. Participants were severely deconditioned (VO2 peak: 19 ± 4 mL/kg/min; GS: 0.88 ± 0.28 m/s; TUG: 12.6 ± 5.9 s; 6MWD: 295 ± 121 m) and at elevated metabolic risk (HOMA-IR: 6.3 ± 4.5). The dietary intake ratio of omega-6/omega-3 fatty acids averaged 12.6 ± 7.1 and the serum concentration ratio was 1.21 ± 0.37, which were correlated (r = 0.88, p < 0.01). Higher dietary intake and serum concentrations of omega-6/omega-3 fatty acids were associated with lower 6MWD and higher HOMA-IR, while a higher serum omega-6/omega-3 concentration index was associated with lower VO2 peak (p’s < 0.05). These preliminary data suggest that both dietary omega-6 and omega-3 fatty acids (quantitated as their intake ratio) and the serum concentration ratio of omega-6/omega-3 may be important indices of physical dysfunction and insulin resistance in chronic stroke survivors. Copyright 2020 by the authors.en_US
dc.description.sponsorshipThis study was supported by funds from a Career Development Award IK2-RX-000944 (MCS) and a Senior Research Career Scientist Award (ASR) from the Department of Veterans Affairs Rehabilitation R&D Service and the Birmingham/Atlanta, San Antonio, and Baltimore GRECCs.en_US
dc.description.urihttps://doi.org/10.3390/nu12030701en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofNutrients
dc.subjectInsulin resistanceen_US
dc.subjectOmega-3en_US
dc.subjectOmega-6en_US
dc.subjectPhysical functionen_US
dc.subjectStrokeen_US
dc.titleDietary and serum omega-6/omega-3 fatty acids are associated with physical and metabolic function in stroke survivorsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/nu12030701


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