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    Perfect timing: Circadian rhythms, sleep, and immunity - An NIH workshop summary

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    Author
    Haspel, J.A.
    Anafi, R.
    Mongodin, E.
    Date
    2020
    Journal
    JCI Insight
    Publisher
    American Society for Clinical Investigation
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1172/jci.insight.131487
    Abstract
    Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation - are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.
    Sponsors
    Pfizer
    Keyword
    Circadian Rhythm
    Sleep
    Adaptive Immunity
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079551046&doi=10.1172%2fjci.insight.131487&partnerID=40&md5=21e325cf33b20c6245b69fd8d655b7c9; http://hdl.handle.net/10713/12133
    ae974a485f413a2113503eed53cd6c53
    10.1172/jci.insight.131487
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