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    Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls

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    Author
    DiChiacchio, L.
    Singh, A.K.
    Shockcor, N.M.
    Zhang, T.
    Lewis, B.G.
    Mohiuddin, M.M.
    Date
    2019
    Journal
    Frontiers in Cardiovascular Medicine
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fcvm.2019.00095
    Abstract
    Heterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone toward the development of a life-supporting animal model, with the ultimate goal of demonstrating suitability for clinical cardiac xenotransplantation trials. Aspects of surgical technique, pre- and post-operative care, graft monitoring, and minimization of infectious risk have all required refinement and optimization of heterotopic cardiac xenotransplantation over time. This review details non-immunologic obstacles relevant to this model described by our group and in the literature, as well as strategies that have been developed to address these specific challenges. Copyright 2019 The Authors.
    Sponsors
    NIAID/NIH Grant #5U19AI090959-10.
    Keyword
    abdominal
    baboon
    cardiac
    complications
    heterotopic
    pig
    xenograft
    xenotransplant
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079388536&doi=10.3389%2ffcvm.2019.00095&partnerID=40&md5=5c61ad205f8babc42e841fb06ac00717; http://hdl.handle.net/10713/12071
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcvm.2019.00095
    Scopus Count
    Collections
    UMB Open Access Articles 2019

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