Detection and quantification of renal fibrosis by computerized tomography
PublisherPublic Library of Science
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AbstractObjectives: Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility. Methods: We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated nonhuman primates. Results: Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93. Conclusions: This metric is a promising and simple non-invasive biomarker for renal fibrosis. Copyright 2020 Carvalho et al.
SponsorsU19A167798, P30CA012197; National Cancer Institute, NCI
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079339150&doi=10.1371%2fjournal.pone.0228626&partnerID=40&md5=f723f2eb97fec539612fe89576501462; http://hdl.handle.net/10713/12056