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    Factors influencing malignant mesothelioma survival: A retrospective review of the national mesothelioma virtual bank cohort

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    Author
    Amin, W.
    Linkov, F.
    Friedberg, J.S.
    Date
    2018
    Journal
    F1000Research
    Publisher
    F1000 Research Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.12688/F1000RESEARCH.15512.3
    Abstract
    Background: Malignant mesothelioma (MM) is a rare but deadly malignancy with about 3,000 new cases being diagnosed each year in the US. Very few studies have been performed to analyze factors associated with mesothelioma survival, especially for peritoneal presentation. The overarching aim of this study is to examine survival of the cohort of patients with malignant mesothelioma enrolled in the National Mesothelioma Virtual Bank (NMVB). Methods: 888 cases of pleural and peritoneal mesothelioma cases were selected from the NMVB database, which houses data and associated biospecimens for over 1400 cases that were diagnosed from 1990 to 2017. Kaplan Meier’s method was performed for survival analysis. The association between prognostic factors and survival was estimated using Cox Hazard Regression method and using R software for analysis. Results: The median overall survival (OS) rate of all MM patients, including pleural and peritoneal mesothelioma cases is 15 months (14 months for pleural and 31 months for peritoneal). Significant prognostic factors associated with improved survival of malignant mesothelioma cases in this NMVB cohort were younger than 45, female gender, epithelioid histological subtype, stage I, peritoneal occurrence, and having combination treatment of surgical therapy with chemotherapy. Combined surgical and chemotherapy treatment was associated with improved survival of 23 months in comparison to single line therapies. Conclusions: There has not been improvement in the overall survival for patients with malignant mesothelioma over many years with current available treatment options. Our findings show that combined surgical and chemotherapy treatment in peritoneal mesothelioma is associated with improved survival compared to local therapy alone. Copyright 2019 Amin W et al.
    Sponsors
    This work is funded and supported by the Centers for Disease Control and Prevention (CDC) in association with the National Institute for Occupational Safety and Health (NIOSH) Grant [5U24OH009077-11].
    Keyword
    Biobanking
    Cox hazard regression analysis
    Mesothelioma
    Risk factor
    Survival analysis
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079140440&doi=10.12688%2fF1000RESEARCH.15512.3&partnerID=40&md5=b85e656b72f09c565f6063fea72b2cd5; http://hdl.handle.net/10713/12036
    ae974a485f413a2113503eed53cd6c53
    10.12688/F1000RESEARCH.15512.3
    Scopus Count
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