Spatial Network Connectivity and Spatial Reasoning Ability in Children with Nonverbal Learning Disability
MetadataShow full item record
AbstractNonverbal Learning Disability (NVLD) is characterized by deficits in visual-spatial, but not verbal, reasoning. Nevertheless, the functioning of the neural circuits supporting spatial processing have yet to be assessed in children with NVLD. We compared the resting state functional connectivity of a spatial brain network among children with NVLD, children with reading disorder (RD), and typically developing (TD) children. Seventy-five participants (7-15 years old) were included in the study (20 TD, 24 NVLD, and 31 RD). Group differences in global efficiency and functional connectivity among 12 regions comprising a previously defined spatial network were evaluated. Associations with behavior were explored. Global efficiency of the spatial network associated positively with spatial ability and inversely with socioemotional problems. Within the spatial network, associations between left posterior cingulate (PCC) and right retrosplenial cortical activity were reduced in children with NVLD relative to those without spatial deficits (RD and TD). Connectivity between left PCC and right posterior cerebellum (Crus I and II) was reduced in both groups of children with learning disabilities (NVLD and RD) relative to TD children. Functional connectivity of the spatial network was atypically associated with cognitive and socioemotional performance in children with NVLD. Identifying a neurobiological substrate for NVLD provides evidence that it is a discrete clinical entity and suggests targets for treatment. Copyright 2020, The Author(s).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078060364&doi=10.1038%2fs41598-019-56003-y&partnerID=40&md5=8c76a822d96b2100c331c0ab60b4ace0; http://hdl.handle.net/10713/11996
- Salience network connectivity and social processing in children with nonverbal learning disability or autism spectrum disorder.
- Authors: Margolis AE, Pagliaccio D, Thomas L, Banker S, Marsh R
- Issue date: 2019 Jan
- Comprehension of humor in children with nonverbal learning disabilities, reading disabilities, and without learning disabilities.
- Authors: Semrud-Clikeman M, Glass K
- Issue date: 2008 Dec
- Neural correlates of cognitive control deficits in children with reading disorder.
- Authors: Margolis AE, Pagliaccio D, Davis KS, Thomas L, Banker SM, Cyr M, Marsh R
- Issue date: 2019 Mar 28
- Auditory processing disorder in children diagnosed with nonverbal learning disability.
- Authors: Keller WD, Tillery KL, McFadden SL
- Issue date: 2006 Dec