• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    The G⁸⁹⁴-T⁸⁹⁴ exon 7 polymorphism in the endothelial nitric oxide synthase gene and blood pressure in a cohort of lead-exposed workers from Korea

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Lustberg, Mark E.
    Advisor
    Silbergeld, Ellen K.
    Date
    2002
    Type
    dissertation
    
    Metadata
    Show full item record
    See at
    http://search.proquest.com/docview/305528342/
    Abstract
    Research question. Is the G-T polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene associated with increased blood pressure or increased susceptibility to the effects of lead on blood pressure in a cohort of lead-exposed workers from Korea? Background. Hypertension effects 24% of adult Americans, and increases risk of adverse cardiovascular outcomes. Several modifiable risk factors for hypertension have been identified, including overweight, poor diet, and physical inactivity. Some studies suggest that lead-exposure may be a modifiable risk factor for hypertension. Recently, interest has focused on genetic polymorphisms as susceptibility factors for hypertension. As nitric oxide (NO) is a central mediator of blood pressure homeostasis, polymorphisms in the gene for endothelial nitric oxide synthase (eNOS) have been theorized to be susceptibility factors for hypertension. Some---but not all---studies have found that the T-allele (the minor allele) of a G-T nucleotide substitution polymorphism in exon 7 of the eNOS gene is associated with increased risk of hypertension. This finding is support by reports suggesting that NO production may be decreased in individuals with the T-variant allele. Methods. 793 lead-exposed workers were genotyped for the polymorphism using a PCR-based assay. Regression was used to model the genotype-blood pressure association and genotype as an effect-modifier of the lead-blood pressure association. Age, gender, BMI, education, smoking, and alcohol consumption were included in the model. Results. 84.9% of individuals were homozygous GG, 14.4% were heterozygous GT, and 0.8% were homozygous TT. The T-allele was not significantly associated with systolic or diastolic blood pressure. After adjustment for potential confounders, individuals with the T-allele had 0.7 +/- 1.5 mm Hg lower systolic blood pressure and 0.1 +/- 1.0 mm Hg than those without the allele [+/-SE]. After adjustment for potential confounders, a 10-percentile increase in tibia lead was associated with a 0.08 +/- 0.45 mm Hg increase in systolic blood pressure in those with the T-allele, and a 0.62 +/- 0.21 mm Hg increase in systolic blood pressure in those without the allele (interaction effect not significant). Conclusions: These data provide no evidence for increased blood pressure or increased sensitivity to the effects of lead on blood pressure in individuals with the T-allele.
    Description
    University of Maryland, Baltimore. Epidemiology and Public Health. Ph.D. 2002
    Keyword
    Biology, Biostatistics
    Biology, Genetics
    Health Sciences, Public Health
    Hypertension--etiology
    Korea
    Lead--adverse effects
    Polymorphism, Genetic
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1173
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.