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dc.contributor.authorRodriguez, S.
dc.contributor.authorLittle, H.C.
dc.contributor.authorWoodward, O.M.
dc.date.accessioned2020-02-05T14:36:41Z
dc.date.available2020-02-05T14:36:41Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078679115&doi=10.1096%2ffj.201900558RR&partnerID=40&md5=c25374a0922e1952f660630626de48f5
dc.identifier.urihttp://hdl.handle.net/10713/11707
dc.description.abstractLocal and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF-related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence here that CTRP1 also modulates renal physiology in an age- and sex-dependent manner. In mice lacking CTRP1, we observed significantly increased kidney weight and glomerular hypertrophy in aged male but not female or young mice. Although glomerular filtration rate, plasma renin and aldosterone levels, and renal response to water restriction did not differ between genotypes, CTRP1-deficient male mice had elevated blood pressure. Echocardiogram and pulse wave velocity measurements indicated normal heart function and vascular stiffness in CTRP1-deficient animals, and increased blood pressure was not due to greater salt retention. Paradoxically, CTRP1-deficient mice had elevated urinary sodium and potassium excretion, partially resulting from reduced expression of genes involved in renal sodium and potassium reabsorption. Despite renal hypertrophy, markers of inflammation, fibrosis, and oxidative stress were reduced in CTRP1-deficient mice. RNA sequencing revealed alterations and enrichments of genes in metabolic processes in CTRP1-deficient animals. These results highlight novel contributions of CTRP1 to aging-associated changes in renal physiology.en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Grant Numbers: DK084171, F31DK116537, DK107726; American Diabetes Association (ADA). Grant Number: 1?18?PMF?022; National Heart, Lung, and Blood Institute (NHLBI). Grant Number: HL128512en_US
dc.description.urihttps://doi.org/10.1096/fj.201900558RRen_US
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofFASEB Journal
dc.subjectaging-associated renal physiologyen_US
dc.subjectC1q/TNF-related protein 1en_US
dc.subjectkidney functionen_US
dc.titleLate-onset renal hypertrophy and dysfunction in mice lacking CTRP1en_US
dc.typeArticleen_US
dc.identifier.doi10.1096/fj.201900558RR
dc.identifier.pmid31908037


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