Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1
Date
2019Journal
FASEB JournalPublisher
John Wiley and Sons Inc.Type
Article
Metadata
Show full item recordAbstract
Local and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF-related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence here that CTRP1 also modulates renal physiology in an age- and sex-dependent manner. In mice lacking CTRP1, we observed significantly increased kidney weight and glomerular hypertrophy in aged male but not female or young mice. Although glomerular filtration rate, plasma renin and aldosterone levels, and renal response to water restriction did not differ between genotypes, CTRP1-deficient male mice had elevated blood pressure. Echocardiogram and pulse wave velocity measurements indicated normal heart function and vascular stiffness in CTRP1-deficient animals, and increased blood pressure was not due to greater salt retention. Paradoxically, CTRP1-deficient mice had elevated urinary sodium and potassium excretion, partially resulting from reduced expression of genes involved in renal sodium and potassium reabsorption. Despite renal hypertrophy, markers of inflammation, fibrosis, and oxidative stress were reduced in CTRP1-deficient mice. RNA sequencing revealed alterations and enrichments of genes in metabolic processes in CTRP1-deficient animals. These results highlight novel contributions of CTRP1 to aging-associated changes in renal physiology.Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Grant Numbers: DK084171, F31DK116537, DK107726; American Diabetes Association (ADA). Grant Number: 1?18?PMF?022; National Heart, Lung, and Blood Institute (NHLBI). Grant Number: HL128512Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078679115&doi=10.1096%2ffj.201900558RR&partnerID=40&md5=c25374a0922e1952f660630626de48f5; http://hdl.handle.net/10713/11707ae974a485f413a2113503eed53cd6c53
10.1096/fj.201900558RR
Scopus Count
Collections
Related articles
- Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.
- Authors: Rodriguez S, Little HC, Daneshpajouhnejad P, Fenaroli P, Tan SY, Sarver DC, Delannoy M, Talbot CC Jr, Jandu S, Berkowitz DE, Pluznick JL, Rosenberg AZ, Wong GW
- Issue date: 2021 Jan 1
- A novel blood pressure modulator C1q/TNF-α-related protein 1 (CTRP1).
- Authors: Han S, Yang Y
- Issue date: 2018 Dec
- Loss of CTRP1 disrupts glucose and lipid homeostasis.
- Authors: Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW
- Issue date: 2016 Oct 1
- C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.
- Authors: Kanemura N, Shibata R, Ohashi K, Ogawa H, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Otaka N, Murohara T, Ouchi N
- Issue date: 2017 Feb
- C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart.
- Authors: Yuasa D, Ohashi K, Shibata R, Mizutani N, Kataoka Y, Kambara T, Uemura Y, Matsuo K, Kanemura N, Hayakawa S, Hiramatsu-Ito M, Ito M, Ogawa H, Murate T, Murohara T, Ouchi N
- Issue date: 2016 Mar