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    Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1

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    Author
    Rodriguez, S.
    Little, H.C.
    Woodward, O.M.
    Date
    2019
    Journal
    FASEB Journal
    Publisher
    John Wiley and Sons Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1096/fj.201900558RR
    Abstract
    Local and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF-related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence here that CTRP1 also modulates renal physiology in an age- and sex-dependent manner. In mice lacking CTRP1, we observed significantly increased kidney weight and glomerular hypertrophy in aged male but not female or young mice. Although glomerular filtration rate, plasma renin and aldosterone levels, and renal response to water restriction did not differ between genotypes, CTRP1-deficient male mice had elevated blood pressure. Echocardiogram and pulse wave velocity measurements indicated normal heart function and vascular stiffness in CTRP1-deficient animals, and increased blood pressure was not due to greater salt retention. Paradoxically, CTRP1-deficient mice had elevated urinary sodium and potassium excretion, partially resulting from reduced expression of genes involved in renal sodium and potassium reabsorption. Despite renal hypertrophy, markers of inflammation, fibrosis, and oxidative stress were reduced in CTRP1-deficient mice. RNA sequencing revealed alterations and enrichments of genes in metabolic processes in CTRP1-deficient animals. These results highlight novel contributions of CTRP1 to aging-associated changes in renal physiology.
    Sponsors
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Grant Numbers: DK084171, F31DK116537, DK107726; American Diabetes Association (ADA). Grant Number: 1?18?PMF?022; National Heart, Lung, and Blood Institute (NHLBI). Grant Number: HL128512
    Keyword
    aging-associated renal physiology
    C1q/TNF-related protein 1
    kidney function
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078679115&doi=10.1096%2ffj.201900558RR&partnerID=40&md5=c25374a0922e1952f660630626de48f5; http://hdl.handle.net/10713/11707
    ae974a485f413a2113503eed53cd6c53
    10.1096/fj.201900558RR
    Scopus Count
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    UMB Open Access Articles 2019

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