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dc.contributor.authorNasrin, D.
dc.contributor.authorKotloff, K.L.
dc.contributor.authorTennant, S.M.
dc.date.accessioned2020-02-04T17:04:32Z
dc.date.available2020-02-04T17:04:32Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85077941694&doi=10.1128%2fmSphere.00735-19&partnerID=40&md5=71a2eaf55322beb002eee4274164deb2
dc.identifier.urihttp://hdl.handle.net/10713/11675
dc.description.abstractCampylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asia, we examined fecal microbial compositions, bacterial isolates, and their carbohydrate metabolic pathways in Campylobacter-positive infants <1 year of age from the Global Enterics Multicenter Study. Exclusively breastfed infants with diarrhea exhibited high Campylobacter abundances, and this negatively correlated with bacterial carbohydrate metabolism. Although C. jejuni and Campylobacter coli are prevalent among these infants, the second most abundant Campylobacter species was a new species, which we named "Candidatus Campylobacter infans." Asymptomatic Campylobacter carriers also possess significantly different proportions of specific gut microbes compared to diarrheal cases. These findings provide insight into Campylobacter infections in infants in sub-Saharan Africa and South Asia and help inform strategies aimed at eliminating campylobacteriosis in these areas.IMPORTANCECampylobacter is the primary cause of bacterial diarrhea in the United States and can lead to the development of the postinfectious autoimmune neuropathy known as Guillain-Barré syndrome. Also, drug-resistant campylobacters are becoming a serious concern both locally and abroad. In low- and middle-income countries (LMICs), infection with Campylobacter is linked to high rates of morbidity, growth stunting, and mortality in children, and breastfeeding is important for infant nutrition, development, and protection against infectious diseases. In this study, we examined the relationship between breastfeeding and Campylobacter infection and demonstrate the increased selection for C. jejuni and C. coli strains unable to metabolize fucose. We also identify a new Campylobacter species coinfecting these infants with a high prevalence in five of the seven countries in sub-Saharan Africa and South Asia examined. These findings indicate that more detailed studies are needed in LMICs to understand the Campylobacter infection process in order to devise a strategy for eliminating this pathogenic microbe. Copyright 2020 Bian et al.en_US
dc.description.sponsorshipThis work was supported by U.S. Department of Agriculture Agricultural Research Service CRIS project 2030-42000-051-00D.
dc.description.urihttps://doi.org/10.1128/mSphere.00735-19en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofmSphere
dc.subjectbreastfeedingen_US
dc.subjectCampylobacteren_US
dc.subjectGEMSen_US
dc.subjectl-fucose metabolismen_US
dc.subject"Candidatus Campylobacter infans," gut microbiomeen_US
dc.titleCampylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/mSphere.00735-19
dc.identifier.pmid31941810


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