Campylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
PublisherAmerican Society for Microbiology
MetadataShow full item record
AbstractCampylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asia, we examined fecal microbial compositions, bacterial isolates, and their carbohydrate metabolic pathways in Campylobacter-positive infants <1 year of age from the Global Enterics Multicenter Study. Exclusively breastfed infants with diarrhea exhibited high Campylobacter abundances, and this negatively correlated with bacterial carbohydrate metabolism. Although C. jejuni and Campylobacter coli are prevalent among these infants, the second most abundant Campylobacter species was a new species, which we named "Candidatus Campylobacter infans." Asymptomatic Campylobacter carriers also possess significantly different proportions of specific gut microbes compared to diarrheal cases. These findings provide insight into Campylobacter infections in infants in sub-Saharan Africa and South Asia and help inform strategies aimed at eliminating campylobacteriosis in these areas.IMPORTANCECampylobacter is the primary cause of bacterial diarrhea in the United States and can lead to the development of the postinfectious autoimmune neuropathy known as Guillain-Barré syndrome. Also, drug-resistant campylobacters are becoming a serious concern both locally and abroad. In low- and middle-income countries (LMICs), infection with Campylobacter is linked to high rates of morbidity, growth stunting, and mortality in children, and breastfeeding is important for infant nutrition, development, and protection against infectious diseases. In this study, we examined the relationship between breastfeeding and Campylobacter infection and demonstrate the increased selection for C. jejuni and C. coli strains unable to metabolize fucose. We also identify a new Campylobacter species coinfecting these infants with a high prevalence in five of the seven countries in sub-Saharan Africa and South Asia examined. These findings indicate that more detailed studies are needed in LMICs to understand the Campylobacter infection process in order to devise a strategy for eliminating this pathogenic microbe. Copyright 2020 Bian et al.
SponsorsThis work was supported by U.S. Department of Agriculture Agricultural Research Service CRIS project 2030-42000-051-00D.
"Candidatus Campylobacter infans," gut microbiome
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85077941694&doi=10.1128%2fmSphere.00735-19&partnerID=40&md5=71a2eaf55322beb002eee4274164deb2; http://hdl.handle.net/10713/11675
- The other Campylobacters: Not innocent bystanders in endemic diarrhea and dysentery in children in low-income settings.
- Authors: François R, Yori PP, Rouhani S, Siguas Salas M, Paredes Olortegui M, Rengifo Trigoso D, Pisanic N, Burga R, Meza R, Meza Sanchez G, Gregory MJ, Houpt ER, Platts-Mills JA, Kosek MN
- Issue date: 2018 Feb
- Prospective study of enteric Campylobacter infections in children from birth to 6 months in the Central African Republic.
- Authors: Georges-Courbot MC, Beraud-Cassel AM, Gouandjika I, Georges AJ
- Issue date: 1987 May
- Magnitude of Rotavirus A and Campylobacter jejuni infections in children with diarrhea in Twin cities of Rawalpindi and Islamabad, Pakistan.
- Authors: Sadiq A, Bokhari H, Noreen Z, Asghar RM, Bostan N
- Issue date: 2019 Nov 21
- Immunoglobulin A antibodies directed against Campylobacter jejuni flagellin present in breast-milk.
- Authors: Nachamkin I, Fischer SH, Yang XH, Benitez O, Cravioto A
- Issue date: 1994 Apr
- Enhanced microbiological surveillance reveals that temporal case clusters contribute to the high rates of campylobacteriosis in a model agroecosystem.
- Authors: Inglis GD, Boras VF, Webb AL, Suttorp VV, Hodgkinson P, Taboada EN
- Issue date: 2019 May - Jun