• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2020
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2020
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Piao, W.
    Xiong, Y.
    Li, L.
    Saxena, V.
    Paluskievicz, C.
    Willsonshirkey, M.
    Bromberg, J.S.
    Date
    2020
    Journal
    Cell Reports
    Publisher
    Elsevier B.V.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.celrep.2019.12.083
    Abstract
    Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions, and chemokines. We demonstrate a role for Tregs through this pathway to condition the permissiveness of lymphatic endothelia for transendothelial migration (TEM), thus gating leukocyte traffic. Human Tregs share the same property with murine Tregs. Activation of TLR2 on Tregs during inflammation specifically augments LTα1β2-LTβR signaling, which further enhances the permissiveness of LECs to facilitate TEM. The conditioning of endothelia may promote the resolution of inflammation by directing leukocytes out of tissues to lymphatic vessels and draining lymph nodes (dLNs). Thus, Tregs interact with lymphatic endothelia under homeostasis and inflammation and dictate endothelial permissiveness and gating mechanisms for subsequent leukocyte migration through endothelial barriers. © 2019 Piao et al.
    Sponsors
    This work was supported by NIH grant RO1 AI062765 to J.S.B., the Maryland Living Legacy Foundation to J.S.B. and W.P., R01 AI126596 and R01 HL141815 to R.A., RO1 CA72669 to B.R.B., and R01 HL11879 and P01 CA 065493 to B.R.B. and K.L.H.
    Keyword
    lymphatic endothelial cells
    lymphotoxin
    regulatory T cells
    Toll-like receptor 2
    transendothelial migration
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078324997&doi=10.1016%2fj.celrep.2019.12.083&partnerID=40&md5=0a53e6924365b48aab98078d25098535; http://hdl.handle.net/10713/11653
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.celrep.2019.12.083
    Scopus Count
    Collections
    UMB Open Access Articles 2020

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.