• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Sex differences in soman-induced toxicity and response to medical countermeasures in serum carboxylesterase knockout mice

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Kundrick_umaryland_0373N_11118.pdf
    Size:
    630.9Kb
    Format:
    PDF
    Download
    Author
    Kundrick, Erica cc
    0000-0002-4222-1528
    Advisor
    Pereira, Edna F. R.
    Lumley, Lucille A.
    Date
    2019
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    In rodents, exposure to chemical warfare nerve agent soman leads to status epilepticus and extensive neuronal loss. Mice and rats are less sensitive to nerve agent toxicity compared to primates since high levels of plasma carboxylesterase, which acts as a bioscavenger against soman, increase resistance of these rodents to organophosphorus poisoning. One objective of this research project was to determine the LD50s of soman in female plasma carboxylesterase knockout (ES1-/-) mice at the different stages of their estrous cycle and to compare toxicity across estrous and with male mice. Female mice in estrus were less susceptible to the soman lethality compared to female mice in proestrus and to male mice. The second objective was to evaluate dose-response effects of delayed midazolam treatment in soman-exposed ES1-/- mice. Delayed midazolam dose-dependently increased survival and reduced seizure severity but did not prevent epileptogenesis or brain pathology in seizure-sensitive brain regions, independent of sex.
    Description
    2019
    Toxicology
    University of Maryland, Baltimore
    M.S.
    Keyword
    Toxicology
    Neurosciences
    Female
    Mice, Knockout
    Midazolam--therapeutic use
    Soman--adverse effects
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/11616
    Collections
    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.