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    Neural and behavioral changes driven by observationally-induced hypoalgesia

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    Author
    Raghuraman, N.
    Wang, Y.
    Furman, A.J.
    Tricou, C.
    Seminowicz, D.A.
    Colloca, L.
    Date
    2019
    Journal
    Scientific Reports
    Publisher
    Nature Research
    Type
    Article
    
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    https://doi.org/10.1038/s41598-019-56188-2
    Abstract
    Observing successful pain treatment in others can induce anticipatory neural processes that, in turn, relieve pain. Previous studies have suggested that social learning and observation influence placebo hypoalgesia. Here, we used electroencephalography (EEG) to determine the neurophysiological changes associated with pain relief acquired through the observation. Thirty-one participants observed a demonstrator undergo painful heat stimulations paired with a “control” cream and non-painful ones paired with a “treatment” cream, which actually were both Vanicreams. After their observation, the participants then received the same creams and stimulations. We found that the treatment cream led to lower self-reported pain intensity ratings than the control cream. Anticipatory treatment cues elicited smaller P2 in electrodes F1, Fz, FC1, and FCz than the control condition. The P2 component localization indicated a higher current density in the right middle frontal gyrus, a region associated with attentional engagement. In placebo responders, the sensorimotor cortex activity captured in electrodes C3, Cz, and C4 indicated that hypoalgesia was positively correlated with resting state peak alpha frequency (PAF). These results suggest that observationally-induced placebo hypoalgesia may be driven by anticipatory mechanisms that modulate frontal attentional processes. Furthermore, resting state PAF could serve as a predictor of observationally-induced hypoalgesia. Copyright 2019, The Author(s).
    Sponsors
    This research was supported by the Dean's Initiative Fund, University of Maryland School of Nursing (LC), University of Maryland Baltimore, Institute for Clinical & Translational Research (ICTR) and related NCATS (1UL1TR003098-01), and NCCIH (1R01 AT010333-01A1, LC) grants.
    Keyword
    observationally-induced placebo hyopalgesia
    Pain Perception--physiology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077171011&doi=10.1038%2fs41598-019-56188-2&partnerID=40&md5=4180b18a30c70d112eb93ea337b5bcfb; http://hdl.handle.net/10713/11569
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-56188-2
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