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dc.contributor.authorLomeli, B.K.
dc.contributor.authorGalbraith, H.
dc.contributor.authorRavel, J.
dc.date.accessioned2020-01-08T12:55:01Z
dc.date.available2020-01-08T12:55:01Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85077017112&doi=10.1128%2fAAC.01395-19&partnerID=40&md5=13d520a795bae29897c7577480b3bfe3
dc.identifier.urihttp://hdl.handle.net/10713/11565
dc.description.abstractCRS3123 is a novel small molecule that potently inhibits methionyl-tRNA synthetase of Clostridioides difficile, inhibiting C. difficile toxin production and spore formation. CRS3123 has been evaluated in a multiple-ascending-dose placebo-controlled phase 1 trial. Thirty healthy subjects, ages 18 to 45 years, were randomized into three cohorts of 10 subjects each, receiving either 200, 400, or 600 mg of CRS3123 (8 subjects per cohort) or placebo (2 subjects per cohort) by oral administration twice daily for 10 days. CRS3123 was generally safe and well tolerated, with no serious adverse events (SAEs) or severe treatment-emergent adverse events (TEAEs) reported. All subjects completed their assigned treatment and follow-up visits, and there were no trends in systemic, vital sign, or laboratory TEAEs. There were no QTcF interval changes or any clinically significant changes in other electrocardiogram (ECG) intervals or morphology. CRS3123 showed limited but detectable systemic uptake; although absorption increased with increasing dose, the increase was less than dose proportional. Importantly, the bulk of the oral dose was not absorbed, and fecal concentrations were substantially above the MIC90 value of 1 μg/ml at all dosages tested. Subjects receiving either of the two lower doses of CRS3123 exhibited minimal disruption of normal gut microbiota after 10 days of twice-daily dosing. CRS3123 was inactive against important commensal anaerobes, including Bacteroides, bifidobacteria, and commensal clostridia. Microbiome data showed favorable differentiation compared to other CDI therapeutics. These results support further development of CRS3123 as an oral agent for the treatment of CDI. (This study has been registered at Clinicaltrials.gov under identifier NCT02106338.). Copyright 2019 Lomeli et al.en_US
dc.description.urihttps://doi.org/10.1128/AAC.01395-19en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofAntimicrobial agents and chemotherapy
dc.subjectantibioticen_US
dc.subjectClostridioides difficileen_US
dc.subjectCRS3123en_US
dc.subjectgut microbiotaen_US
dc.subjectMAD studyen_US
dc.subjectmicrobiomeen_US
dc.subjectnarrow spectrumen_US
dc.subjectphase 1en_US
dc.subjectsporulationen_US
dc.subjecttoxin productionen_US
dc.titleMultiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiotaen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/AAC.01395-19
dc.identifier.pmid31685472


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