• Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.

      Stewart, Christopher C; O'Hara, Nathan N; Bzovsky, Sofia; Bahney, Chelsea S; Sprague, Sheila; Slobogean, Gerard P (British Editorial Society of Bone & Joint Surgery, 2022-04)
      A total of 102 participants aged 18 to 50 years (median 28 years (interquartile range 23 to 35)), receiving an intramedullary nail for a tibial or femoral shaft fracture, were enrolled in a randomized controlled trial comparing vitamin D3 supplementation to placebo. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption marker) and N-terminal propeptide of type I procollagen (P1NP; bone formation marker) were measured at baseline, six weeks, and 12 weeks post-injury. Clinical and radiological fracture healing was assessed at three months.