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    Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology

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    Author
    Newman, A.B.
    Kritchevsky, S.B.
    Guralnik, J.M.
    Date
    2020
    Journal
    The journals of gerontology. Series A, Biological sciences and medical sciences
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/gerona/glz230
    Abstract
    BACKGROUND: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. METHODS: Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. RESULTS: Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. CONCLUSIONS: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span. Copyright The Author(s) 2019.
    Sponsors
    National Institute on Aging, National Institute of Health, United Kingdom Medical Research Council, etc.
    Keyword
    Epidemiology
    Longevity
    Successful aging
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076450074&doi=10.1093%2fgerona%2fglz230&partnerID=40&md5=0039b2cd1fd334848b7b208a759a31ab; http://hdl.handle.net/10713/11532
    ae974a485f413a2113503eed53cd6c53
    10.1093/gerona/glz230
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