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dc.contributor.authorSchwartz, L.M.
dc.contributor.authorZaman, K.
dc.contributor.authorNeuzil, K.M.
dc.date.accessioned2019-12-11T19:48:28Z
dc.date.available2019-12-11T19:48:28Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073814108&doi=10.1093%2fcid%2fciz133&partnerID=40&md5=3ed81310126cc64a9f9d28b750ed6902
dc.identifier.urihttp://hdl.handle.net/10713/11515
dc.description.abstractBACKGROUND: Following the conclusion of a human rotavirus vaccine (HRV) cluster-randomized, controlled trial (CRT) in Matlab, Bangladesh, HRV was included in Matlab's routine immunization program. We describe the population-level impact of programmatic rotavirus vaccination in Bangladesh in children <2 years of age. METHODS: Interrupted time series were used to estimate the impact of HRV introduction. We used diarrheal surveillance collected between 2000 and 2014 within the 2 service delivery areas (International Centre for Diarrhoeal Disease Research, Bangladesh [icddr,b] service area [ISA] and government service area [GSA]) of the Matlab Health and Demographic Surveillance System, administered by icddr,b. Age group-specific incidence rates were calculated for both rotavirus-positive (RV+) and rotavirus-negative (RV-) diarrhea diagnoses of any severity presenting to the hospital. We used 2 models to assess the impact within each service area: Model 1 used the pre-vaccine time period in all villages (HRV- and control-only) and Model 2 combined the pre-vaccine time period and the CRT time period, using outcomes from control-only villages. RESULTS: Both models demonstrated a downward trend in RV+ diarrheal incidences in the ISA villages during 3.5 years of routine HRV use, though only Model 2 was statistically significant. Significant impacts of HRV on RV+ diarrhea incidences in GSA villages were not observed in either model. Differences in population-level impacts between the 2 delivery areas may be due to the varied rotavirus vaccine coverage and presentation rates to the hospital. CONCLUSIONS: This study provides initial evidence of the population-level impact of rotavirus vaccines in children <2 years of age in Matlab, Bangladesh. Further studies are needed of the rotavirus vaccine impact after the nationwide introduction in Bangladesh. Copyright: The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.en_US
dc.description.sponsorshipThis work was supported by the Bill & Melinda Gates Foundation (grant number OPP1097672) and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) (grant number MERIT R37 AI032042).en_US
dc.description.urihttps://doi.org/10.1093/cid/ciz133en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dc.subjectimpacten_US
dc.subjectrotavirus vaccineen_US
dc.subjecttime-seriesen_US
dc.titleImpact of Rotavirus Vaccine Introduction in Children Less Than 2 Years of Age Presenting for Medical Care With Diarrhea in Rural Matlab, Bangladeshen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/ciz133
dc.identifier.pmid30753368


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