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dc.contributor.authorSingh, Prernaen_US
dc.date.accessioned2019-12-10T13:19:34Z
dc.date.available2019-12-10T13:19:34Z
dc.date.issued2019en_US
dc.identifier.urihttp://hdl.handle.net/10713/11502
dc.description2019
dc.descriptionMolecular Medicine
dc.descriptionUniversity of Maryland, Baltimore
dc.descriptionM.S.
dc.description.abstractChordomas are a rare slow-growing cancer and their standard of care is surgery with Radiotherapy (RT). Chordoma is highly radioresistant and requires high dose of RT that lead to toxicity in the surrounding tissues. We investigated whether proton beam radiation therapy (PBRT) response can be further enhanced in combination with hyperthermia (HT) as a radiosensitizer. We also explored cell survival at the end of the Spread-out Bragg Peak (E-SOBP) compared to middle of the SOBP (M-SOBP) of PBRT with and without HT. Chordoma cell lines were treated with HT followed by PBRT at both E-SOBP and M-SOBP. Clonogenic assay was performed in triplicates for a dose response survival. HT with PBRT significantly killed (p<0.05) more cells at M-SOBP and E-SOBP compared to PBRT without HT. Our results provide in vitro evidence on effects of HT as a novel additive treatment to increase PBRT effectiveness in Chordoma cell lines.
dc.subjectproton radiationen_US
dc.subjectradiation therapyen_US
dc.subject.lcshCanceren_US
dc.subject.meshChordomaen_US
dc.subject.meshHyperthermia, Induceden_US
dc.subject.meshProton Therapyen_US
dc.subject.meshRadiotherapyen_US
dc.titleTHE EFFECT OF HYPERTHERMIA AND PROTON RADIATION THERAPY ON CHORDOMA CELLS
dc.typedissertationen_US
dc.date.updated2019-12-09T23:00:23Z
dc.language.rfc3066en
dc.contributor.advisorMahmood, Javed
refterms.dateFOA2019-12-10T13:19:34Z


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