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    THE EFFECT OF HYPERTHERMIA AND PROTON RADIATION THERAPY ON CHORDOMA CELLS

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    Author
    Singh, Prerna
    Advisor
    Mahmood, Javed
    Date
    2019
    Type
    dissertation
    
    Metadata
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    Abstract
    Chordomas are a rare slow-growing cancer and their standard of care is surgery with Radiotherapy (RT). Chordoma is highly radioresistant and requires high dose of RT that lead to toxicity in the surrounding tissues. We investigated whether proton beam radiation therapy (PBRT) response can be further enhanced in combination with hyperthermia (HT) as a radiosensitizer. We also explored cell survival at the end of the Spread-out Bragg Peak (E-SOBP) compared to middle of the SOBP (M-SOBP) of PBRT with and without HT. Chordoma cell lines were treated with HT followed by PBRT at both E-SOBP and M-SOBP. Clonogenic assay was performed in triplicates for a dose response survival. HT with PBRT significantly killed (p<0.05) more cells at M-SOBP and E-SOBP compared to PBRT without HT. Our results provide in vitro evidence on effects of HT as a novel additive treatment to increase PBRT effectiveness in Chordoma cell lines.
    Description
    2019
    Molecular Medicine
    University of Maryland, Baltimore
    M.S.
    Keyword
    proton radiation
    radiation therapy
    Cancer
    Chordoma
    Hyperthermia, Induced
    Proton Therapy
    Radiotherapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/11502
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    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

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