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dc.contributor.authorCollins, K.D.
dc.date.accessioned2019-12-04T15:55:05Z
dc.date.available2019-12-04T15:55:05Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85075115564&doi=10.1017%2fS0033583519000106&partnerID=40&md5=1210a5ac72c2eab41e0b0792e9098206
dc.identifier.urihttp://hdl.handle.net/10713/11467
dc.description.abstractThe strong, long-range electrostatic forces described by Coulomb’s law disappear for ions in water, and the behavior of these ions is instead controlled by their water affinity – a weak, short-range force which arises from their charge density. This was established experimentally in the mid-1980s by size-exclusion chromatography on carefully calibrated Sephadex® G-10 (which measures the effective volume and thus the water affinity of an ion) and by neutron diffraction with isotopic substitution (which measures the density and orientation of water molecules near the diffracting ion and thus its water affinity). These conclusions have been confirmed more recently by molecular dynamics simulations, which explicitly model each individual water molecule. This surprising change in force regime occurs because the oppositely charged ions in aqueous salt solutions exist functionally as ion pairs (separated by 0, 1 or 2 water molecules) as has now been shown by dielectric relaxation spectroscopy; this cancels out the strong long-range electrostatic forces and allows the weak, short-range water affinity effects to come to the fore. This microscopic structure of aqueous salt solutions is not captured by models utilizing a macroscopic dielectric constant. Additionally, the Law of Matching Water Affinity, first described in 1997 and 2004, establishes that contact ion pair formation is controlled by water affinity and is a major determinant of the solubility of charged species since only a net neutral species can change phases.en_US
dc.description.urihttps://doi.org/10.1017/S0033583519000106en_US
dc.language.isoen_USen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofQuarterly reviews of biophysics
dc.subjectIonsen_US
dc.subjectLaw of Matching Water Affinityen_US
dc.subjectproteinsen_US
dc.subjectwateren_US
dc.subjectwater affinityen_US
dc.titleThe behavior of ions in water is controlled by their water affinityen_US
dc.typeArticleen_US
dc.identifier.doi10.1017/S0033583519000106
dc.identifier.pmid31735174


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