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dc.contributor.authorZalzman, M.
dc.contributor.authorMeltzer, W.A.
dc.contributor.authorPortney, B.A.
dc.contributor.authorBrown, R.A.
dc.contributor.authorGupta, A.
dc.date.accessioned2019-12-04T15:55:04Z
dc.date.available2019-12-04T15:55:04Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85075530797&doi=10.21775%2fcimb.035.085&partnerID=40&md5=bdaf1d99fa02e0a2d14c6bf55278abc5
dc.identifier.urihttp://hdl.handle.net/10713/11460
dc.description.abstractTelomeres are a unique structure of DNA repeats covered by proteins at the ends of the chromosomes that protect the coding regions of the genome and function as a biological clock. They require a tight regulation of the factors covering and protecting their structure, as they are shortened with each cell division to limit the ability of cells to replicate uncontrollably. Additionally, they protect the chromosome ends from DNA damage responses and thereby, prevent genomic instability. Telomere dysfunction can lead to chromosomal abnormalities and cancer. Therefore, dysregulation of any of the factors that regulate the integrity of the telomeres will have implications to chromosomal stability, replicative lifespan and may lead to cell transformation. This review will cover the main factors participating in the normal function of the telomeres and how these are regulated by the ubiquitin and SUMO systems. Accumulating evidence indicate that the ubiquitin and SUMO pathways are significant regulators of the shelterin complex and other chromatin modifiers, which are important for telomere structure integrity. Furthermore, the crosstalk between these two pathways has been reported in telomeric DNA repair. A better understanding of the factors contributing to telomere biology, and how they are regulated, is important for the design of new strategies for cancer therapies and regenerative medicine. Copyright 2020, Caister Academic Press. All rights reserved.en_US
dc.description.urihttps://doi.org/10.21775/cimb.035.085en_US
dc.language.isoen_USen_US
dc.publisherCaister Academic Pressen_US
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.subject.meshSumoylationen_US
dc.subject.meshTelomere Homeostasis--physiologyen_US
dc.subject.meshUbiquitinen_US
dc.titleThe role of ubiquitination and SUMOylation in telomere biologyen_US
dc.typeArticleen_US
dc.identifier.doi10.21775/cimb.035.085
dc.identifier.pmid31422934


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